Utility of Erythrocyte Indices for Screening of Β – Thalassemia Trait in Pregnant Women Attending Antenatal Clinic
نویسندگان
چکیده
Background: This study was undertaken to see the utility of erythrocyte indices for screening of beta thalassemia trait in pregnant women, as these indices are based on complete blood count reports which are routinely available and nowadays generated by automated hematology analyzer. Material and methods: The study was a cross sectional in which the complete blood count report of 300 pregnant women attending antenatal clinic mahila chikitsalaya,sms medical college, Jaipur with microcytosis (MCV <80fl) was analyzed. Four red blood cell indices namely – Mentzer index, England Fraser index, RBC count & Green king index were calculated for all patients from the complete blood count (CBC) reports. Among these, for those patients who were suspected to have beta thalassemia trait on the basis of the red blood cell indices , Hb A2 estimation by high performance liquid chromatography (HPLC), serum iron, total iron binding capacity (TIBC) & serum ferritin was done. The collected data was analyzed statistically and the sensitivity & specificity of the four red blood cell indices was calculated & compared according to Youdens test. Results: In our study the patients in the beta thalassemia trait group had significantly decreased mean corpuscular volume(MCV), mean corpuscular hemoglobin(MCH)and packed cell volume(PCV) compared to those in non beta thalassemia group. Mentzer index was the best among the four discrimination indices used. Green king index and Mentzer index,when both indices are combined this yield is more informative.Conclusion: Mentzer index is a useful screening test for detection of beta thalassemia trait.
منابع مشابه
Antenatal screening for identification of couples for prenatal diagnosis of severe hemoglobinopathies in surat, South gujarat.
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